Abstract:To summarize the nursing experience of an elderly diabetic patient with facial squamous carcinoma complicated by multiple skin reactions after comprehensive treatment. Key points of skin care: comprehensively evaluate the process of radiotherapy, the timing of medication, and the manifestations of skin lesions, and identify the type and degree of skin damage. For radiation dermatitis, basic prevention and protection, eschar softening and debridement, drug spraying repair, dot dressing stitching, shaping bandaging and fixation are used to promote wound healing. For cancerous wounds, the four core symptoms of cancerous wounds, including pain, exudation, bleeding, and malodor, are effectively managed through wound flushing, drainage of necrotic tissue to reduce tension, effective drainage of fistula, and protection of surrounding skin. For skin toxic reaction, blister treatment, wound wet compress, drug spray, dressing and other measures are used to promote skin healing. Key points of mucosal care: use negative pressure sponge brush and medication to keep the oral cavity clean and prevent infection, spray cell stimulating factor to promote the regeneration of oral mucosa, rinse the eye and surrounding secretions, and use ophthalmic ointment and vaseline gauze to moisturize the conjunctiva as to prevent ulceration. Key points of systemic support care: effective prevention of infection and analgesia, reasonable nutritional support to control blood glucose, observation of the adverse effects of hormone therapy, mobilization of family resources to provide psychological support. The patient was successfully discharged from the hospital after 38 days of hospitalization. The follow-up of 1 week, 1 month, 3 months, and 6 months after discharge showed that the local and systemic skin recovered well, and the body weight and nutritional indicators remained normal.