甲状腺癌术后患者用药科普干预及效果评价★

Medication knowledge popularization intervention on thyroid cancer patients after surgery and its effect evaluation★

摘要:

目的 探讨用药科普干预在分化型甲状腺癌术后患者中的应用效果。方法 以2020年4月—2021年6月住院手术治疗的甲状腺癌患者100例为研究对象，按入院先后将其分为观察组和对照组，每组50例。对照组患者予以常规健康宣教，观察组在对照组基础上对患者进行用药科普干预。比较两组患者入院时和出院后第6个月Morisky用药依从性调查表评分，出院后第1、6个月的血清促甲状腺激素（TSH）水平达标率，术后1年肿瘤复发情况及治疗过程中药物不良反应发生情况。结果 两组患者入院时用药依从性调查表评分比较，差异无统计学意义（P>0.05）；观察组患者出院后第6个月复诊时用药依从性调查表评分明显高于对照组（P<0.05）。两组患者出院后第1个月复诊时血清TSH达标率比较，差异无统计学意义（P>0.05）；观察组患者出院后第6个月复诊时血清TSH达标率明显高于对照组（P<0.05）。随访1年，观察组患者未出现肿瘤复发情况，且观察组患者药物不良反应发生例数少于对照组。结论 对甲状腺癌术后患者进行临床用药科普干预，可提高患者服药依从性和血清TSH水平达标率，并降低肿瘤复发和药物不良反应。

Abstract:

Objective To investigate the effect of medication knowledge popularization on patients with differentiated thyroid cancer post-surgery.Methods A total of 100 patients who underwent thyroid cancer surgery between April 2020 and June 2021 were selected in this study and randomly divided into the observation group and the control group, each group with 50 patients. Patients in the control group received the standard health education, while those in the observation group received medication knowledge popularization intervention on the base of the control group. Comparison was made between the two groups based on Morisky Medication Adherence Scale (MMAS) scores at the first day of hospitalization and 6 months post-discharge, the percentage of patients with satisfied serum thyroid-stimulating hormone (TSH) levels at 1 month and 6 months post-discharge, tumor recurrence rate at one year after surgery, and the incidence rate of adverse drug reactions during treatment.Results There was no significant difference in MMAS scores between the two groups at the first day of hospitalization (P>0.05). However, at 6 months post-discharge, the MMAS scores of the observation group were significantly higher than those of the control group (P<0.05). At 1 month post-discharge, there was no significant difference in the percentages of patients with satisfied TSH levels between the two groups (P>0.05). But at 6 months post-discharge, the observation group had a higher percentage of patients who maintained TSH level at the recommended level than the control group (P<0.05). After 1 year of follow-up, no tumor recurrence was observed in the observation group, and there was less cases of adverse drug reactions observed in the observation group than in the control group.Conclusion The popularization of medication knowledge for thyroid cancer patients after surgery can improve their medication compliance, maintain their serum TSH levels in a recommended level, and reduce the incidence of tumor recurrence and adverse drug reactions.