SENP1在肺癌病理生物学中的作用★

The role of SENP1 in lung cancer pathobiology★

摘要:

SENP1是一种参与去SUMO化的蛋白质，是肿瘤发生和复发、转移的一个危险因素，与多种肿瘤的发生、侵袭、转移及耐药相关，其在肿瘤组织中的表达具有十分重要的意义。SENP1通过与多种分子、靶蛋白相互作用调控细胞周期、促进肿瘤血管生成、参与细胞铁死亡等，导致肺癌的复发和转移，是肺癌患者预后不良的影响因素。本文对SENP1及其靶蛋白在肿瘤发生发展中的作用机制、对肺癌耐药和预后的影响进行总结。

Abstract:

SENP1, a protein involved in de-SUMOylation, is a risk factor for tumor occurrence, recurrence and metastasis. It is associated with the occurrence, invasion, metastasis and drug resistance of a variety of tumors. Its expression in tumor tissues is of great significance. SENP1 contributes to the recurrence and metastasis of lung cancer by interacting with a variety of molecules and target proteins to regulate the cell cycle, promote the tumor angiogenesis, and participate in cellular iron death, etc. SENP1 is an affecting factor for the poor prognosis of lung cancer. In this paper, we reviewed the mechanism of SENP1 and its targeting proteins in tumor development, and their effects on drug resistance and prognosis of lung cancer.