基于多学科协作的延续护理在卡培他滨联合奥沙利铂方案治疗老年结直肠癌患者中的效果分析

Continuous nursing based on multidisciplinary cooperation in capecitabine combined with oxaliplatin treatment of elderly colorectal cancer patients

摘要:

目的 分析基于多学科协作的延续护理在卡培他滨联合奥沙利铂方案治疗老年结直肠癌中的效果。方法 选取2016年6月至2019年1月于我院接受卡培他滨联合奥沙利铂方案治疗的70例老年结直肠癌患者，随机分为观察组（35例）与对照组（35例）。对照组予以常规院内护理及出院健康指导，观察组在对照组基础上给予基于多学科协作的延续护理干预。比较两组干预前后的生活质量、负性情绪、血管新生因子及免疫细胞水平的差异。结果 干预后，两组患者SAS、SDS评分均明显低于干预前，且观察组显著低于对照组（P<0.01）；两组患者bFGF、VEGF-A水平均明显低于干预前，且观察组显著低于对照组（P<0.01）；两组患者NK、CD4^＋水平及CD4⁺/CD8⁺均明显高于干预前，且观察组显著高于对照组（P<0.05）；两组患者CD8⁺水平均明显低于干预前，且观察组显著低于对照组（P<0.01）；两组患者生活质量各维度评分均明显高于干预前，且观察组显著高于对照组（P<0.05）。结论 对于接受卡培他滨联合奥沙利铂方案治疗的老年结直肠癌患者，基于多学科协作的延续护理干预能有效缓解其负性情绪，有助于提高其生活质量及维持免疫功能稳定，控制病情的进一步发展。

Abstract:

Objective To analyze the effects of continuous nursing based on multidisciplinary cooperation on the elderly colorectal cancer patients treated with capecitabine combined with oxaliplatin regimen.Methods Seventy elderly patients with colorectal cancer who received capecitabine combined with oxaliplatin between June 2016 and January 2019 were randomly divided into observation group (n=35) and control group (n=35). The control group was given routine in-hospital nursing and out-hospital health guidance. The observation group was added with continuous nursing intervention based on multi-disciplinary cooperation. Compare the scores of quality of life and negative emotion, the angiogenesis factors and immune cell levels between the two groups before and after intervention.Results After intervention, both groups had significantly lower SAS and SDS scores than before intervention, and the observation group had lower SAS and SDS scores than the control group (P<0.01). Also, both groups had significantly lower bFGF and VEGF-A levels than before intervention, and the observation group had even lower bFGF and VEGF-A levels than the control group (P<0.01). The levels of NK and CD4⁺, and the CD4⁺/CD8⁺ in the two groups were significantly higher than those before intervention, and they were significantly higher in the observation group than in the control group (P<0.05). The CD8⁺ level in both groups was significantly lower than before intervention, and it was lower in the observation group than in the control group (P<0.01). Moreover, the scores of the dimensions of quality of life in both groups were significantly higher than before intervention, and they were also higher in the observation group than in the control group (P<0.05).Conclusion Continuous nursing intervention based on multidisciplinary cooperation can effectively alleviate the negative emotions of elderly patients with colorectal cancer treated by capecitabine combined with oxaliplatin regimen, and help to improve their quality of life and maintain the stability of immune function, so that can control the disease.