他莫昔芬治疗乳腺癌-直肠癌同时性多原发癌1例★

A case of simultaneous multiple primary cancers of the breast and rectum treated with tamoxifen★

摘要:

目的 探讨同时性多原发癌（MPC）的临床特征及治疗方案。方法 以1例乳腺癌-直肠癌同时性MPC的病例报道为切入点，查阅文献，总结并分析其临床特征及治疗方案。结果 出现乳腺癌-直肠癌同时性MPC可能是多种致病因素共同作用的结果，患者先后接受乳腺全切术与直肠癌根治术，术后一直口服他莫昔芬（TAM）辅助治疗，患者恢复良好，复查未见异常，病情稳定。结论 乳腺癌-直肠癌同时性MPC术后采用TAM治疗对乳腺癌的疗效显著，患者病情稳定无进展，但TAM对直肠癌的疗效有待进一步阐明。MPC的早诊、早治至关重要，可通过多学科诊疗模式，制定个体化治疗方案。

Abstract:

Objective To investigate the clinical characteristics and treatment options for simultaneous multiple primary cancers (MPC).Methods Using a case report of simultaneous MPC of the breast and rectum as an entry point, we reviewed the literature to summarize and analyze its clinical features and treatment programs.Results In this case, the development of simultaneous MPC of the breast and rectum may be the result of a combination of pathogenic factors.She underwent total mastectomy and radical rectal cancer surgery successively, and has been taking oral tamoxifen (TAM) as adjuvant therapy after the surgery. The patient has recovered well, and no abnormality has been found in the review, and she has the disease stable.Conclusion For simultaneous MPC of breast-rectal cancer, the efficacy of TAM for breast cancer is remarkable. Although in this case the disease was stable and progression-free after postoperative TAM treatment, the efficacy of TAM for rectal cancer needs to be further elucidated. In addition, early diagnosis and treatment are crucial for MPC patients, and individualized treatment plans need to be developed through a multidisciplinary diagnostic and treatment model.