Objective To observe the clinical characteristics of ovarian cancer patients receiving bevacizumab combined with TC chemotherapy regimen resulting in thrombocytopenia, to explore the therapeutic regimen and pharmacological supervision. Methods Clinical pharmacists analyzed the clinical data of one ovarian cancer patient using bevacizumab combined with TC chemotherapy regimen resulting in thrombocytopenia, and reviewed the literature to optimize the treatment plan, and assisted the doctors to jointly provide pharmacological supervision for the patient. Results With supervision of clinical pharmacists, the patient was improved after receiving platelet elevating therapy, and the platelet count indexes rose to the normal level. Conclusion Clinical pharmacists provide pharmacological monitoring for patients during their treatment from a professional perspective, and assist clinicians in formulating individualized treatment plans, which helps to ensure the safety of patients" medication and promote the rational use of medication.