基于AHP-TOPSIS法评价聚乙二醇化粒细胞刺激因子合理应用情况

Evaluation of rational application of pegylated granulocyte stimulating factor based on AHP-TOPSIS method

摘要:

目的：建立聚乙二醇化粒细胞刺激因子（PEGylated granulocyte stimulating factor，PEG-rhG-CSF）合理评价体系，为评价PEG-rhG-CSF合理性应用提供参考。方法：以PEG-rhG-CSF说明书、相关指南等为依据，制定 PEG-rhG-CSF合理性评价细则，通过层次分析法计算各评价指标权重，采用优劣解距离法对广州市第一人民医院2021年1-6月使用PEG-rhG-CSF的患者进行合理性分析。结果：建立包括3个一级指标和10个二级指标的评价体系。在纳入的612份病例中，用药完全合理占28.76%，基本合理占55.23%，不合理占16.01%。结论：通过AHP-TOPSIS法合理性评价，发现某院PEG-rhG-CSF的应用基本合理，但在给药时机、给药适应症、给药剂量上仍存在较大的不合理性，需进一步改善。

Abstract:

Objective: To establish a rational evaluation system for PEGylated granulocyte stimulating factor （PEG-rhG-CSF), and to provide reference for evaluating the rational application of PEG-rhG-CSF. Methods: Based on PEG-rhG-CSF instructions and related guidelines, etc., formulate detailed rules for rationality evaluation of PEG-rhG-CSF, then the weight of each evaluation index was calculated through Analytical Hierarchy Process. The Technique for Order Preference by Similarity to Solution was used to rationally analyze the patients who received PEG-rhG-CSF from January 2021 to June 2021 in Guangzhou First People"s Hospital. Results: The establishment of the evaluation system includes 3 primary indicators and 10 secondary indicators. Among the 612 cases, 28.76% were completely reasonable, 55.23% were basically reasonable, and 16.01% were unreasonable. Conclusion: Through the rationality evaluation of AHP-TOPSIS method, it is found that the application of PEG-rhG-CSF in a hospital is basically reasonable, but there are still large irrationalities in administration timing, administration indications, and administration dosage, which need to be further improved.